Many claims are made about noopept and its potential to boost mood, reduce anxiety, and lower stress. However, unless these claims are backed by hard science and large-scale clinical trials, they should be taken with a pinch of salt.
Noopept is a cycloprolylglycine prodrug that produces brain-derived neurotrophic factor (BDNF). This increases the production of neurotransmitters. It also protects cells from glutamate toxicity and apoptosis.
Boosts Brain Function
Noopept is a nootropic supplement that boosts cognitive function and memory. It does this by increasing oxygen levels and the metabolic activity of mitochondria, which power brain cells and other vital organs. This results in greater mental energy, motivation and focus.
It does this by boosting the release of BDNF and altering neurotransmitter systems. As a prodrug, noopept converts to the cycloprolylglycine dipeptide, which stimulates BDNF production in your brain and supports neurotransmitter systems. It also increases your acetylcholine levels, which improves memory formation and concentration.
Noopept can also prevent the accumulation of oxidative damage in neurons and reduce the production of free radicals, which is associated with Alzheimer’s symptoms. It has been shown to protect neurons from b-amyloid toxicity in cell studies, and it may be able to slow down the progression of Alzheimer’s disease. This is based on one animal study, however, and so further research in humans would be needed to confirm these findings.
Improves Memory
Noopept is a popular cognitive enhancer within the nootropic community, and dozens of studies support its claims of improving memory. Noopept modulates the AMPA and NMDA receptors, both of which are related to how your brain uses glutamate. In addition, it increases the availability of acetylcholine at the synapse, making your memories more accessible.
In one animal study, noopept normalized the ability to form and retain a memory in rats with damaged cerebral cortexes. It also promoted training capacity in rats with hereditary learning deficits.
Alpha and beta brain-wave activity are increased when taking noopept, and these waves are associated with a calm focus and mental clarity. In an experiment, noopept prevented the formation of amyloid plaque in neurons by inhibiting oxidative damage and decreasing tau phosphorylation. It also reduced “learned helplessness” in rats, a common symptom of anxiety and depression. [1]
Reduces the Risk of Dementia
Buy noopept Europe works on certain neurotransmitters to promote a healthy brain, improve concentration and focus, and increase verbal fluency. By increasing the availability of acetylcholine, it boosts cognition and helps you to learn faster and remember things more clearly. It also promotes neuroplasticity in your brain by acting on AMPA glutamate receptors to ensure a quick transmission of signals between neurons.
It has also been shown to enhance the production of nerve growth factor, brain-derived neurotrophic factor (BDNF), and mRNA. NGF and BDNF are directly related to neuroplasticity and can help you repair damage, grow new brain cells, and reduce the risk of cognitive decline.
Although nootropics can offer some incredible benefits, they aren’t a substitute for getting enough sleep, eating a nutrient-dense diet, and reducing stress. However, noopept does appear to reduce the risk of dementia by promoting healthy neurons and preventing oxidative stress and cell death. It’s also believed to prevent some of the symptoms associated with Alzheimer’s and Parkinson’s disease.
Reduces Stress
Noopept stimulates the interaction between two brain regions that enhance how we interpret stimuli, develop new thoughts and ideas and improve memory functioning. It also increases tonic inhibition in the hippocampus which reduces anxiety and stress, boosts dopamine levels, promotes a happier mood and improves sleep quality.
Noopept is believed to increase nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are proteins needed for the growth of neurons in the brain. This explains why it is believed to improve cognition and provide neuroprotective effects both in animal studies and human tests.
In one animal study noopept treatment significantly reduced the level of intracellular calcium, reactive oxygen species, and tau phosphorylation at Ser396 induced by amyloid beta peptide exposure. It also improved the mitochondrial membrane potential, preventing oxidative damage and cell death.
This is based on just one animal study, and more research would be required to determine whether these findings are relevant to humans, too. In addition, noopept is not well-studied and there are no hard data on its possible side-effects or interactions with other medications and compounds.
